Admissions 2024

Department of Biosciences

Dr. Sharanya Suresh C

Designation : Scientist B

Qualification : Ph.D

Email-ID : sharanya@rajagiri.edu

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  • Ph. D Biotechnology, Kannur University, Kerala (2021)
  • PG Diploma in Drug Discovery & Designing, IUCB, Kannur University, Kerala (2014) (81%)
  • MSc. Biotechnology, Cochin University, Kerala (2010) (83%)
  • BSc. Biotechnology, Kannur University, Kerala (2008) (81%)
  • Research Scholar (Kannur University) 2014-2021.
  • Senior Research Fellow (SRF) Council of Scientific and Industrial Research: Kannur University (2017-2020)
  • Junior Research Fellow (JRF): Inter-University Centre for Biosciences, Kannur University (2013-2016) 
  • Computational Biology
  • Structural Biology
  • Drug Discovery & Designing
  • Phytochemistry
  • Ethnopharmacology
  • Phytomedicine
  • Metabolomics
  • Junior Research Fellow of the Project “Discovery of new compounds and developing them as phytopharmaceuticals‟ IUCB, Kannur University (2013- 2016)
  • CSIR, Senior Research Fellowship for the project entitled “Isolation of novel compounds from medicinal plants and transforming them as multifunctional drug candidates by in vitro and in silico methods”

PATENT: Filed (1)

  • Novel carboxyl derivatives of methyl gallate having lipoxygenase inhibitory activity; an in silico and in vitro study (Patent filed No: 202141036648)

Research Articles:

  • Sharanya, C.; Jayanandan, A.; Abdulhameed, S.; Haridas, M. COVID-19 Omicron Variant-Inhibitory in Silico Evidence for Phytocompounds of an Ancient Ayurvedic Formulation; 2022. https://doi.org/10.26434/chemrxiv-2022-wwnts.
  • Abhithaj, J.; Francis, D.; C S, S.; K G, A.; C, S.; Variyar, E. J. Repurposing Simeprevir, Calpain Inhibitor IV and a Cathepsin F Inhibitor against SARS-CoV-2 and Insights into Their Interactions with Mpro. J Biomol Struct Dyn 2022, 40 (1), 325–336. https://doi.org/10.1080/07391102.2020.1813200.
  • Sharanya, C. S.; Sabu, A.; Haridas, M. Potent Phytochemicals against COVID-19 Infection from Phyto-Materials Used as Antivirals in Complementary Medicines: A Review. Future Journal of Pharmaceutical Sciences 2021, 7 (1), 113. https://doi.org/10.1186/s43094-021-00259-7.
  • Premrajan, P.; Jayananadan, A.; Suresh, S. C.; Variyar, E. J. Protective Effects of Phytocompounds from Alpinia Calcarata (Haw.) Roscoe in Freund’s Adjuvant Induced Arthritis in Rats. IJEB Vol.59(03) [March 2021] 2021
  • Sharanya, C. S.; Kumar, A.; J, A.; A, S.; Madathilkovilakathu, H. Drug Repurposing for COVID-19 from FDA Approved and Experiment Stage Drugs by in Silico Methods with SARS CoV-2 Spike Protein. 2020. https://doi.org/10.26434/chemrxiv.12324980.v1.
  • Sharanya, C. S.; Arun, K. G.; Sabu, A.; Haridas, M. Aloe Emodin Shows High Affinity to Active Site and Low Affinity to Two Other Sites to Result Consummately Reduced Inhibition of Lipoxygenase. Prostaglandins Other Lipid Mediat 2020, 150, 106453. https://doi.org/10.1016/j.prostaglandins.2020.106453.
  • Ramesh, S.; Sharanya, C.; Chandra, D.; Variyar, E. J.; Jayanandan, A. A Tale of Two Medicinal Plants: A Comparative Study of Medicinal Bioactivity of Homoeopathic Tinctures of Coleus Aromaticus and Coleus Zeylanicus. 2020.
  • Arun, K. G.; Sharanya, C. S.; Abhithaj, J.; Sadasivan, C. Repurposing of Streptomyces Antibiotics as Adenosine Deaminase Inhibitors by Pharmacophore Modeling, Docking, Molecular Dynamics, and in Vitro Studies. J Recept Signal Transduct Res 2020, 40 (1), 77–88. https://doi.org/10.1080/10799893.2020.1715432.
  • Arun, K. G.; Sharanya, C. S.; Abhithaj, J.; Sadasivan, C. In Silico and in Vitro Validation of Some Benzimidazole Derivatives as Adenosine Deaminase Inhibitors. IJC-B Vol.59B(08) [August 2020] 2020.
  • Arun, K. G.; Sharanya, C. S.; Abhithaj, J.; Francis, D.; Sadasivan, C. Drug Repurposing against SARS-CoV-2 Using E-Pharmacophore Based Virtual Screening, Molecular Docking and Molecular Dynamics with Main Protease as the Target. J Biomol Struct Dyn 2020, 1–12. https://doi.org/10.1080/07391102.2020.1779819.
  • Sharanya, C.; Ali, S.; Abdulhameed, S.; Haridas, M. Fermentation of Polyherbal Preparations as in Ayurveda: A Novel Protocol for Drug-Lead Discovery. 2019.
  • Arun, K.; C.S, S.; J, A.; C, S. Biochemical and Computational Insights of Adenosine Deaminase Inhibition by Epigallocatechin Gallate. Comput. Biol. Chem. 2019, 83 (C). https://doi.org/10.1016/j.compbiolchem.2019.107111.
  • Abhithaj, J.; Arun, K. G.; Sharanya, C. S.; Haridas, M.; Jayadevi Variyar, E. Isozymes Inhibited by Active Site Blocking: Versatility of Calcium Indifferent Hesperidin Binding to Phospholipase A2 and Its Significance. J Recept Signal Transduct Res 2019, 39 (1), 60–66. https://doi.org/10.1080/10799893.2019.1606239.
  • Tomy, M. J.; Sharanya, C. S.; Mahapatra, D. K.; Suresh, K. I.; Sabu, A.; Haridas, M. In Vitro Assessment of Selected Benzoic Acid Derivatives as Anti-Inflammatory Compounds. JSIR Vol.77(06) [June 2018] 2018.
  • Sharanya, C.; K G, A.; V, V.; A, S.; M, H. Designing of Enzyme Inhibitors Based on Active Site Specificity: Lessons from Methyl Gallate and Its Lipoxygenase Inhibitory Profile. J Recept Signal Transduct Res 2018, 38 (3), 256–265. https://doi.org/10.1080/10799893.2018.1478856.
  • Arun, K. G.; Sharanya, C. S.; Sadasivan, C. Computational and Experimental Validation of Morin as Adenosine Deaminase Inhibitor. Journal of Receptors and Signal Transduction 2018, 38 (3), 240–245. https://doi.org/10.1080/10799893.2018.1476543.
  • Chandra, D. N.; Suresh, C. S.; Kumar, G. A.; Sandeep, P. M.; Sabu, A.; Haridas, M. Implication of Biotransformation of Berberine and Its Derivatives on FtsZ Protein: An in silico Study. IJCBDD 2017, 10 (1), 1. https://doi.org/10.1504/IJCBDD.2017.082797.
  • Beulin, D. S. J.; Radhakrishnan, D.; Suresh, S. C.; Sadasivan, C.; Yamaguchi, M.; Kawabata, S.; Ponnuraj, K. Streptococcus Pneumoniae Surface Protein PfbA Is a Versatile Multidomain and Multiligand-Binding Adhesin Employing Different Binding Mechanisms. The FEBS Journal 2017, 284 (20), 3404–3421. https://doi.org/10.1111/febs.14200.
  • Tomy, M. J.; Sharanya, C. S.; Sabu, A.; Haridas, M. K. High Benzoic Acid Production in a Grape-Based Ayurvedic Medicinal Wine (Asava). Current Science 2016, 111 (11), 1836–1838.
  • Arun, K. G.; Sharanya, C. S.; Sandeep, P. M.; Sadasivan, C. Inhibitory Activity of Hibifolin on Adenosine Deaminase- Experimental and Molecular Modeling Study. Comput Biol Chem 2016, 64, 353–358. https://doi.org/10.1016/j.compbiolchem.2016.08.005.
  • Tomy, M. J.; Sharanya, C. S.; Dileep, K. V.; Prasanth, S.; Sabu, A.; Sadasivan, C.; Haridas, M. Derivatives Form Better Lipoxygenase Inhibitors than Piperine: In Vitro and in Silico Study. Chem Biol Drug Des 2015, 85 (6), 715–721. https://doi.org/10.1111/cbdd.12455.

Chapters Contributed in Books

  • Sharanya CS, Sabu A, Haridas M. Plant Metabolomics: Current Status and Prospects. In: Sukumaran S.T., Sugathan S., Abdulhameed S. (eds) Plant Metabolites: Methods, Applications and Prospects. Springer, Singapore, 2020. https://doi.org/10.1007/978-981-15- 5136-9_1
  • Sharanya CS, Haridas M. Anti- inflammatory Molecules: Enzyme Inhibitors. In Bioresources and Bioprocess in Biotechnology; Springer, Singapore, 2017; pp 201–233.
  • Sharanya CS, Haridas M, Sabu A. Anti-inflammatory herbal molecules. In Medicinal Plants; KSCSTE-Kerala Forest Research Institute, Kerala, 2017; 67-77

Articles in Proceedings//Book of Abstracts:

  • Suresh S, Sabu A, Haridas M. Interaction of aloe-emodin with lipoxygenase towards the development of novel NSAIDs. Eur. J. Immunol. 2016. 46 (Suppl. 1): 1–1274. DOI: 10.1002/eji.201670200
  • Sharanya CS, Noufera KP, Sabu A, Haridas M. Microbial transformation of piperine. Abstracts: Recent Advances in Molecular Biology and Biotechnology, Thavakkara, Kannur, 14-16th March 2018.
  • Kiran M, Sharanya CS, Sabu A, Haridas M (2018). Biotransformation of Solanum xanthocarpum extracts by fermentation. Abstracts: Recent Advances in Molecular Biology and Biotechnology, Thavakkara, Kannur, 14-16th March 2018
  • Sharanya CS, Tomy MJ, Sabu A, Haridas M (2016). LOX inhibition by aloe-emodin: the anti-inflammatory effect of Cassia angustifolia (Vahl). Extended Abstracts: Page No:441-453, 28th Kerala Science Congress, Calicut, Kerala.
  • Sharanya CS, Sreelekshmi AK, Geethanandan K, Haridas M, Variyar EJ. In vitro anti-inflammatory activity of Passiflora incarnata (L). Abstracts: International Symposium on Phytochemistry and Prof. Dr. A. Hisham Endowment Award Ceremony, 27th February 2016.
  • Sharanya CS, Roshla K, Sabu A, Haridas M. Aloe emodin: A natural anthraquinone from Cassia angustifola (Vahl) as lipoxygenase inhibitor. Abstracts: International Symposium on Phytochemistry and Prof. Dr. A. Hisham Endowment Award Ceremony, 25th April 2015.
  • Archana PTK, Sharanya CS, Sabu A, Haridas M (2015). In vitroAnti-inflammatory activity of Achyranthes aspera (L.). Abstracts: International Symposium on Phytochemistry and Prof. Dr. A. Hisham Endowment Award Ceremony, 25th April 2015.
  • Neethumol P, Sharanya CS, Haridas M, Sabu A (2015). 5-Lipoxygenase inhibitory activity of Barringtonia acutangula (L.). Abstracts: International Symposium on Phytochemistry and Prof. Dr. A. Hisham Endowment Award Ceremony, 25th April 2015.
  • Nikhitha A, Sharanya CS, Sabu A, Haridas M (2015). 5-Lipoxygenase inhibitory effect of Artemisia japonica (Thunberg). (2015). Abstracts: International Symposium on Phytochemistry and Prof. Dr. A. Hisham Endowment Award Ceremony, 25th April 2015.
  • Sayana P, Sharanya CS, Haridas M, Sabu A (2015). Methyl gallate: Lipoxygenase inhibitor from Bergenia ligulata (Wall). Abstracts: International Symposium on Phytochemistry and Prof. Dr. A. Hisham Endowment Award Ceremony, 25th April 2015.
  • Sharanya CS, Preethidan DS, Tomy MJ, Haridas KR, Sabu A, Haridas M (2014). Seidenfone: A novel lipoxygenase inhibitor from Seidenfia rheedii (Sw.) (Szkch). Extended Abstracts: Page No: 893-898, 26th Kerala Science Congress, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad, Kerala.
  • Presented poster entitled “Microbial Transformation of Piperine” in three-day National Seminar- RAMBB-2018 organized by Kannur University.
  • Presented poster entitled “In vitro Anti-inflammatory activity of Passiflora incarnata (L)” at International Symposium on Phytochemistry and Prof. (Dr) A. Hisham Endowment Award Ceremony’-2016
  • Presented poster entitled “Aloe emodin: A natural anthraquinone from Cassia angustifolia (Vahl) as Lipoxygenase inhibitor” at International Symposium on Phytochemistry and Prof. Dr A. Hisham Endowment Award Ceremony’-2015
  • Presented Paper entitled “Seidenfone: A Novel Lipoxygenase Inhibitor from Seidenfia rheedii (Sw.) (Szkch)” at 26th Kerala Science Congress (2013).
  • Presented poster entitled “Anti-inflammatory compounds from plants used in Indian Systems of Medicine” at ICABS-2012.
  • Workshop In Bioinformatics: Conducted by Dept. of Biotechnology, K.V.M College of Engineering and Information Technology, Cherthala, Kerala in association with Cedula BioSolutions, Hyderabad (2nd -3rd November 2009) 
  • Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR) (2017-2019)
  • Junior Research Fellowship from Inter-University Centre for Bioscience, Kannur University (2013-16)
  • UGC Scholarship: During PG Diploma in Drug Discovery and Drug Designing, IUCB, Kannur University (2011-2012)
  • Best Poster award (28th Kerala Science congress Organized by KSCSTE, 2016)
  • R&D Co-Ordinator at Inscenario Labs LLP.